- Healing cooling systems in medicine: technotrans steps up activities in the focus market of healthcare

• New product for cooling in cancer therapies in clinical trials

• Cooling application for civilisation and sports diseases in development

• Focus on energy efficiency and climate friendliness

Sassenberg/Baden-Baden, January 28, 2022 – technotrans SE is expanding its solution competence on the focus market healthcare & analytics. In line with its "Future Ready 2025" strategy, the thermal management specialist is currently developing several new cooling solutions for medical applications. The highlight among the new products is the cooling system Cooral® by BrainCool AB, which can be used for patients undergoing chemotherapy. The cooling devices for oral use are effective against the serious side effects of cancer treatment, such as open wounds or the detachment of the mucosal lining of the mouth. After the completion of the clinical trials, the market launch of the solution is planned for this year. In addition, technotrans is developing a cooling cuff for the treatment of civilisation diseases and sports injuries.

Cuff cooling (source: BrainCool AB): The portable system is used to cool the brain for preclinical treatment. The special focus is on the application for concussions caused by sports injuries.

"The healing effect of cold, for exampleapplied to bruises, has been proved for a long time in the medical context. There are numerous ways cooling can be used for this purpose. In view of the growing number of patients suffering from civilisation diseases or sports injuries, we are

convinced that the demand for thermal solutions will increase considerably," says Jan Kröger, managing director of termotek GmbH (in future: technotrans systems GmbH). The potential areas of application of the cooling solutions include joint and tissue injuries, pain treatments, rheumatoid and connective tissue diseases as well as muscle relaxation or the treatment of paralysis.

At present, several technotrans solutions for medical applications are being developed and tested. The highlight among the new products is the cooling system Cooral® by BrainCool AB: technotrans has been working together with this European manufacturer of medical devices for several years to develop cooling attachments for oral use by patients undergoing cancer treatment. Cancer is often treated with chemotherapy. The drugs used for this treatment can have strong side effects, such as open wounds or the detachment of the mucosal lining of the mouth (oral mucositis). These side effects cause considerable pain to the patients and can lead to inflammation or even life-threatening sepsis. Cooling decreases the circulation of blood and the metabolism in the affected areas so that the active ingredients of the drugs do not penetrate the mucous membranes of the mouth. This helps to prevent or at least reduce oral mucositis. At present, the device is in the final project phase. After a successful clinical trial, the market launch is planned for later this year.

Flexible areas of application and energy-efficient operation
Another innovative product is the cooling cuff for the treatment of civilisation diseases and sport injuries such as bruises or rheumatoid disorders. The system consists of a trolley with a hose and a gel cuff for cooling the affected skin area. Thanks to a smart 3D chip, the cooling output is precisely adapted to the patient. In addition, the device can also be used for warming the affected areas. The system only requires very little maintenance and is characterised by its compact size, low noise level and excellent reliability. technotrans uses sustainable natural refrigerants such as propane and isobutane for these devices. The cooling cuff system will undergo clinical tests in 2022.

As a specialist for thermal management solutions, technotrans relies on its long-standing experience in the medical engineering sector when it comes to the development of innovative solutions. The company also develops customised laser cooling solutions for diagnostic and therapeutic purposes. In line with its "Future Ready 2025" group strategy, which identifies the healthcare & analytics sector as an important focus market, technotrans will expand its activities in this field. Michael Finger, spokesman of the Board of Management of technotrans SE, explains what the company has envisioned for this market: "Our aim is to develop compact, safe and technically sophisticated cooling and temperature control solutions for a wide capacity range." The group will focus particularly strongly on a high level of energy efficiency and the environmental friendliness of the devices. "These characteristics are particularly important for systems for thermal applications in the medical sector. That is why sustainability and the lowest possible CO2 footprint play a decisive role in product development," adds Michael Finger.

technotrans cooling system - interior view (source: technotrans SE): The cooling system consists of a trolley with hose and individual gel sleeve. Inside the trolley is the technotrans technology.

About technotrans SE:
technotrans SE is a global technology and service group with its headquarters in Sassenberg in the German Münsterland region. Its application-specific thermal management solutions are the core competence of the company. This also includes the energetic optimisation and control of the temperature of sophisticated technological applications. With 17 sites, the company has a presence in all the major markets worldwide. Based on its "Future Ready 2025" strategy, the group has defined four focus markets: Plastics, Healthcare & Analytics, Energy Management (including E-Mobility, high power charging stations and data centres) and Print. In addition, the technology company provides highly specific solutions for the Laser & Machine Tools market. Furthermore, technotrans offers a wide range of services including, for example, construction site installations, maintenance, repairs, 24/7 spare parts supply and technical documentations. As of 2021, the individual companies of the group – technotrans SE, technotrans solutions GmbH, termotek GmbH, klh Kältetechnik GmbH and Reisner Cooling Solutions GmbH – are unified under the technotrans umbrella brand. An exception is gds GmbH, with its headquarters in Sassenberg, as a full-service supplier of technical documentation services which will remain a separate brand within the group of companies. technotrans SE is listed on the Prime Standard segment (ISIN: DE000A0XYGA7 / WKN: A0X YGA) and has a global workforce of more than 1,400 employees. In the 2020 financial year, the group generated consolidated revenue of €190.5 million.

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Central Marketing

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